Diabetes and Obesity

Inhibition of protein glycation by skins and seeds of the muscadine grape. Farrar JL et al.  Biofactors. 2007; 30(3):193-200.

Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities. J Agric Food Chem. You Q et al. 2011 Sep 14;59(17):9506-11.

Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice. Gourineni V, Shay NF, Chung S, Sandhu AK, Gu L. J Agric Food Chem. 2012 Aug 8;60(31):7674-81.

Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Banini AE et al. Nutrition. 2006 Nov-Dec;22(11-12):1137-45.

Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation. Zhao L et al. Food Funct. 2015 Jul;6(7):2293-302.

Cancer

Anticancer effects of four varieties of muscadine grape. God JM et al. J Med Food. 2007 Mar;10(1):54-9.

The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells.  Mendonca P, Darwish AG, Tsolova V, El-Sharkawy I, Soliman KFA.  Anticancer Res. 2019 Aug;39(8):4043-4053

CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).  Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V.  PLoS One. 2019 Apr 9;14(4):e0214844.

The comparative study among different fractions of muscadine grape ‘Noble’ pomace extracts regarding anti-oxidative activities, cell cycle arrest and apoptosis in breast cancer.  Luo J, Song S, Wei Z, Huang Y, Zhang Y, Lu J.  Food Nutr Res. 2017 Dec 10;61(1):1412795.

Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Weiguang Y et al. Food Research International 2006 39(5).

Extracts from red muscadine and cabernet sauvignon wines induce cell death in MOLT-4 human leukemia cells. Mertens-Talcott SU et al. Food Chem. 2008 Jun 1;108(3):824-32.

Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitisrotundifolia). Mertens-Talcott SU et al. J Agric Food Chem. 2006 Jul 26;54(15):5336-43.

Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Hudson TS et al. Cancer Res. 2007 Sep 1;67(17):8396-405.

Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Burton LJ et al. Carcinogenesis. 2015 Sep;36(9):1019-27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643647/

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.  Ignacio DN, et al.  Heliyon. 2019 Jan 16;5(1):e01128

Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells. Burton LJ et al. BMC Complement Altern Med. 2014 Mar 12;14:97.

Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis.  Burton LJ, et al.  PLoS One. 2016 Oct 18;11(10):e0164115.

Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial.  Paller CJ, et al. Clin Cancer Res. 2018 Jan 15;24(2):306-315.

Phase I study of  muscadine grape extract in advanced malignancy. Rhonda L. Bitting,, et al.  2018. Journal of Clinical Oncology. This phase I study (NCT02583269) assessed safety and tolerability of a proprietary MGE in patients (pts) with advanced solid tumors.

A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination. Paller CJ et al. Prostate. 2015 Oct;75(14):1518-25.

Phenolic Fractions from Muscadine Grape “Noble” Pomace can Inhibit Breast Cancer Cell MDA-MB-231 Better than those from European Grape “Cabernet Sauvignon” and Induce S-Phase Arrest and Apoptosis.  Luo J, et al.  J Food Sci. 2017 May;82(5):1254-1263

Study of anticancer activities of muscadine grape phenolics in vitro. Yi W, et al J Agric Food Chem. 2005 Nov 2;53(22):8804-12..

Gut Health

Activities of muscadine grape skin and quercetin against Helicobacter pylori infection in mice. Brown JC et al. J ApplMicrobiol. 2011 Jan;110(1):139-46.

Antibacterial effects of grape extracts on Helicobacter pylori. Brown JC et al.  Appl Environ Microbiol. 2009 Feb;75(3):848-52.

Muscadine Grape (Vitis rotundifolia) or Wine Phytochemicals Reduce Intestinal Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis. Li R et al. J Agric Food Chem. 2017 Feb 1;65(4):769-776

Understanding the Phenolics in Muscadines

Antioxidant, antibacterial, and antibiofilm properties of polyphenols from muscadine grape (VitisrotundifoliaMichx.) pomace against selected foodborne pathogens. Xu C et al. J Agric Food Chem. 2014 Jul 16;62(28):6640-9.

Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitisrotundifolia (Muscadine Grapes) as determined by HPLC-DAD-ESI-MS(n). Sandhu AK and Gu L. J Agric Food Chem. 2010 Apr 28;58(8):4681-92.

Application of muscadine grape (VitisrotundifoliaMichx.) pomace extract to reduce carcinogenic acrylamide. Xu C et al. Food Chem. 2015 Sep 1;182:200-8.

Ellagic acid and flavonoid antioxidant content of muscadine wine and juice. Talcott ST and Lee JH. J Agric Food Chem. 2002 May 22;50(11):3186-92.

Evaluation of phenolic compounds, antioxidant and antiproliferative activities of 31 grape cultivars with different genotypes.  Xia L, et al.  J Food Biochem. 2019 Jun;43(6):e12626.

High-performance liquid chromatography-mass spectrometry and evaporative light-scattering detector to compare phenolic profiles of muscadine grapes. You Q et al. J Chromatogr A. 2012 Jun 1;1240:96-103.

Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. Yilmaz Y and Toledo RT. J Agric Food Chem. 2004 Jan 28;52(2):255-60.

Polyphenolics in grape seeds-biochemistry and functionality. Shi J et al. J Med Food. 2003 Winter;6(4):291-9.

Other

Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. Mellen PB et al. J Am Coll Nutr. 2010 Oct;29(5):469-75.

Enhancement of resistance to coccidiosis and necrotic enteritis in broiler chickens by dietary muscadine pomace. McDougald LR et al. Avian Dis. 2008 Dec;52(4):646- 51.

Fatty acid composition, oxidative stability, antioxidant and antiproliferative properties of selected cold-pressed grape seed oils and flours. Lutterodt H et al. Food Chem. 2011 Sep 15;128(2):391-9.

Inactivation of Enterobactersakazakii by water-soluble muscadine seed extracts. Kim TJ et al. Int J Food Microbiol. 2009 Feb 28;129(3):295-9.

Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.  Ha JH, et al. J Nutr. 2014 Jun;144(6):799-806.

Polyphenolics from açaí( Euterpe oleracea Mart.) and red muscadine grape (Vitisrotundifolia ) protect human umbilical vascular Endothelial cells (HUVEC) from glucose- and lipopolysaccharide (LPS)-induced inflammation and target microRNA-126. Noratto GD et al. J Agric Food Chem. 2011 Jul 27;59(14):7999-8012.

credit: ncmuscadinegrape.org