Increasing your flavonoid consumption may improve collagen synthesis and bone formation. GSE is high in flavonoids and may help increase your bone density and strength.

Animal studies have found that adding GSE to either a low calcium, standard, or high calcium diet can increase bone density, mineral content, and bone strength (6).

Rheumatoid arthritis is an autoimmune condition that results in severe inflammation and the destruction of bone and joints. Animal studies have shown that GSE may suppress bone destruction in inflammatory autoimmune arthritis (7, 8, 9).

GSE also significantly reduced pain, bony spurs, and joint damage in osteoarthritic mice, improving collagen levels and reducing cartilage loss (10).